Strong evidence supports the effectiveness of intensive lifestyle change interventions, such as the National Diabetes Prevention Program (National DPP) lifestyle change program, for the prevention of type 2 diabetes. Although the benefits of such interventions for diabetes prevention are well-established, less is known about the potential psychosocial benefits. Psychosocial challenges, such as high stress levels, can make it harder for individuals to prevent diabetes, and may contribute, for example, to Black women in the National DPP reporting less weight loss than White women. To better understand the psychosocial impacts of lifestyle change interventions, we evaluated the Black Women’s Health Imperative Change Your Lifestyle. Change Your Life (CYL2) Program, which tailors the National DPP lifestyle change program to meet the needs of Black women. CYL2 includes the use of an app with five customized modules that address psychosocial needs of Black women via a high-touch coaching methodology, delivered through videoconferencing. A total of 57 Black women enrolled in the program and completed self-assessments at baseline, 3, and 6 months. Based on a five-point scale, participants reported mean improvements at 3 and 6 months compared to baseline for social support (+0.182, P=0.54; +0.342, P=0.11), perceived stress (-0.139, P=0.16; -0.181, P=0.07), self-care activities (+0.30, P=0.004; +0.53, P<0.001), self-efficacy for diet (+0.144, P=0.55; +0.448, P=0.008;), and self-efficacy for exercise (+0.175, P=0.67; +0.418, P=0.002). Based on a four-point scale from the Patient Health Questionnaire 2, participants reported mean improvement at 3 and 6 months compared to baseline for depression (-0.289, P=0.011; -0.132, P=0.44). Although not all these associations were statistically significant and the pre-/post-study design did not include a control group, the improvements were across a broad spectrum of psychosocial measures and usually increased over time, which is consistent with CYL2 improving psychosocial well-being. Furthermore, in focus groups, many participants attributed their improved well-being and program success to the cultural tailoring, social support, peer accountability, and psychological safety provided by CYL2. These findings suggest that lifestyle change interventions such as CYL2 can impart psychosocial benefits for Black women that are valuable for overall well-being and that may also lead to greater success in diabetes prevention programs.