Objective/ Purpose: This study aimed to map the 12-month trajectory of circulatory cytokines and depression/anxiety symptoms while examining its relationship with Social Environmental Adversity (SEA) exposure.

Methods: 175 Hispanic breast cancer (BC) patients (stages I-III) were recruited. Patients completed surveys that included the PHQ-8, Adverse Childhood Events (ACE) questionnaire, and the Trauma History Questionnaire. Blood serum and BC tumor samples are being collected. Follow-up assessments will conclude in March 2024.

Results: Participants mean age was 55.69. At baseline, 41.9% reported depression and 35.5% anxiety symptoms. Crime exposure was reported by 43.1%, while 100% experienced general disasters. Sexual/physical abuse was reported by 36.3%, while 25.5% reported exposure to more than 4 ACE events. Correlations were found between depression and serum cortisol levels (p=.026). Depression symptoms were correlated (< 0.05) with several cytokines (MIP, IL-8, FGF2, and IL-1RA). Anxiety symptoms were correlated (< 0.05) with IL-8, MIP, MCP3, TGF, and MIPß. Additional longitudinal analyses are being performed to map the trajectory of circulatory cytokines tumor-associated myeloid/lymphoid-derived cells and examine their relationship with depression/anxiety symptoms.

Conclusion : Findings suggest a complex interplay between immune and mental health factors, emphasizing the need for further exploration into the underlying mechanisms behind these observations. Exposure to traumatic SEA events among our cohort highlights the need to address social inequities.