In Vermont, 21% of adult primary care patients report recent use of CBD, and nation-wide 14% of the population reports using CBD consistently thus there is a critical need for scientific studies evaluating the physiological effects of CBD at recreationally-relevant doses. We are interested in the effect of chronic CBD use on the cardiovascular system, particularly looking at heart rate variability (HRV) as a biomarker for cardiovascular health. Our cross-sectional study leverages wearable sensors (wrist-worn WHOOP bands) to provide continuous, real-time data, yielding insights into the dynamic and individualized physiology of CBD users and non-users. This is particularly important as it pertains to certain biometrics, such as HRV, whose accuracy is limited to assessment at a time before an individual has performed any movement for the day. Additionally, the ability to remotely collect physiological data is particularly advantageous as researchers are located in Vermont, where access to participants is limited due to small population size. Recruitment strategies employ digital platforms, such as Facebook group advertisements, to ensure nationwide-reaching participation and a representative sample across urban and rural regions. To complement WHOOP-recorded biometric data, the study integrates lifestyle profiling through online surveys, including the ASA24 and ACT24, which provide detailed insights into participants' daily activity, diet, and sleep patterns. The combination of biometric data with additional self-reported measures—International Physical Activity Questionnaire, Pittsburgh Sleep Quality Index, Mental Health Continuum Short Form, Global Quality of Life Scale, and PRIMEscreen short food frequency questionnaire —enables a comprehensive assessment of factors influencing HRV. Ultimately, this study aims to explore the potential of wearable technology to provide objective health data and to support more inclusive health interventions, enhancing our understanding of cardiovascular health disparities and the effects of CBD across diverse populations.